MEETING NOTES : Dr. Frohman
Meeting Created: July 20, 2012 9:00 AM
Chicago
Understanding your Pituitary Gland in Health and Disease
Dr. Frohman will present an overview of the pituitary gland. He will cover general aspects of
pituitary function and testing and also review the types of pituitary disease that occur,
including pituitary tumors and Sheehan’s Syndrome. Many people ask and wonder if Growth
Hormone Deficiency can be inherited. Dr. Frohman will also briefly address that concern.
Pituitary
Sheep studies, pulses pulsatile
GH secretion at night, varies with age. Most in teens then downhill, follows diurnal rhythm
High igf= cancer?
Hypothalamus
Chris
Anterior pituitary
ACTH
Cortisol
Then back to hypothalamus
Inhibin to inhibit ovary and testes
Types of tumors
Alpha subunit no signs or symptoms
Microadenoma, macroadenoma
Mass effects
Headache, visual disturbance, neurological damage
Impaired pit function...hypopituitarism
Hypersecretion
Acromegaly
Hands, feet, facial swelling, sleep apnea, snoring, tall, oily skin, increased soft tissue, Goliath, carpal tunnel
TMJ, osteoarthritis
Metabolic changes
Organ enlargement, hypertension
Cushing's
ACTH, cortisol
Acne, hirsuitism, striae, other usual symptoms
Therapy
Surgery
Drugs keto, mifepristone, pasireotide
Radiation stereotactic, gamma knife can cause hypopituitarism
Hypopituitarism
- Primary, Sheehan's syndrome uncommon today
- Genetic
Secondary
- Trauma
- Tumor
- Iatrogenic
- Traumatic brain injury
- Anorexia
- Tumors
- Steroids
- Acute
- Slow
Diagnosis, testing
Q&A
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